Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients

Significant transcriptome alterations are detected in the brain of patients with amyotrophic lateral sclerosis (ALS), including carriers of the C9orf72 repeat expansion and C9orf72-negative sporadic cases. Recently, the expression of repetitive element transcripts has been associated with toxicity a...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Prudencio, Mercedes, Gonzales, Patrick K., Cook, Casey N., Gendron, Tania F., Daughrity, Lillian M., Song, Yuping, Ebbert, Mark T.W., van Blitterswijk, Marka, Zhang, Yong-Jie, Jansen-West, Karen, Baker, Matthew C., DeTure, Michael, Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard, Link, Christopher D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886204/
https://ncbi.nlm.nih.gov/pubmed/28637276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx233
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