Protective role of the lipid phosphatase Fig4 in the adult nervous system

The signaling lipid phosphatidylinositol 3,5-bisphosphate, PI(3,5)P(2), functions in vesicular trafficking through the endo-lysosomal compartment. Cellular levels of PI(3,5)P(2) are regulated by an enzyme complex comprised of the kinase PIKFYVE, the phosphatase FIG4, and the scaffold protein VAC14....

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Publicado en:Hum Mol Genet
Main Authors: Mironova, Yevgeniya A, Lin, Jing-Ping, Kalinski, Ashley L, Huffman, Lucas D, Lenk, Guy M, Havton, Leif A, Meisler, Miriam H, Giger, Roman J
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030899/
https://ncbi.nlm.nih.gov/pubmed/29688489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy145
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