Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice

Maternal obesity has been reported to impair oocyte quality in mice, however, the underlying mechanisms remain unclear. In the present study, by conducting a comparative proteomic analysis, we identified a reduced expression of TIGAR (TP53-induced glycolysis and apoptosis regulator) protein in ovula...

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Publicat a:Mol Cell Proteomics
Autors principals: Wang, Haichao, Cheng, Qing, Li, Xiaoyan, Hu, Feifei, Han, Longsen, Zhang, Hao, Li, Ling, Ge, Juan, Ying, Xiaoyan, Guo, Xuejiang, Wang, Qiang
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030723/
https://ncbi.nlm.nih.gov/pubmed/29776966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000620
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