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Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-initiating Cells from Lung Adenocarcinoma
Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma. This study, investigated the association and impact of the ubiquitin specific peptidase 22 (USP22), an H2Bub1 deubiquitinase, on stem cell-like char...
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| 出版年: | Mol Cancer Res |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6030467/ https://ncbi.nlm.nih.gov/pubmed/29720480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0042 |
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