G9a regulates tumorigenicity and stemness through genome-wide DNA methylation reprogramming in non-small cell lung cancer

BACKGROUND: Eukaryotic histone methyltransferases 2 (EHMT2 or G9A) has been regarded as a potential target for non-small cell lung cancer (NSCLC) therapy. This study investigated the regulatory roles of G9A in tumorigenesis and stemness in NSCLC. We isolated and enriched tumor-initiating cells (TIC)...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Pangeni, Rajendra P., Yang, Lu, Zhang, Keqiang, Wang, Jinhui, Li, Wendong, Guo, Chao, Yun, Xinwei, Sun, Ting, Wang, Jami, Raz, Dan J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7302379/
https://ncbi.nlm.nih.gov/pubmed/32552834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-020-00879-5
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