Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-initiating Cells from Lung Adenocarcinoma

Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma. This study, investigated the association and impact of the ubiquitin specific peptidase 22 (USP22), an H2Bub1 deubiquitinase, on stem cell-like char...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Yun, Xinwei, Zhang, Keqiang, Wang, Jinhui, Pangeni, Rajendra P., Yang, Lu, Bonner, Melissa, Wu, Jun, Wang, Jami, Nardi, Isaac K., Gao, Ming, Raz, Dan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030467/
https://ncbi.nlm.nih.gov/pubmed/29720480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0042
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