IL22 Promotes Kras Mutant Lung Cancer by Induction of a Pro-Tumor Immune Response and Protection of Stemness Properties

Somatic KRAS mutations are the most common oncogenic variants in lung cancer and are associated with poor prognosis. Using a Kras–induced lung cancer mouse model, CC-LR, we previously showed a role for inflammation in lung tumorigenesis through activation of the NF-κB pathway, along with induction o...

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Udgivet i:Cancer Immunol Res
Main Authors: Khosravi, Nasim, Caetano, Mauricio S., Cumpian, Amber M., Unver, Nese, De la Garza Ramos, Cynthia, Noble, Oscar, Daliri, Soudabeh, Hernandez, Belinda J., Gutierrez, Berenice A., Evans, Scott E., Hanash, Samir, Alekseev, Andrei M., Yang, Yi, Chang, Seon Hee, Nurieva, Roza, Kadara, Humam, Chen, Jichao, Ostrin, Edwin J., Moghaddam, Seyed Javad
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030457/
https://ncbi.nlm.nih.gov/pubmed/29764837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0655
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