IL-6 blockade reprograms the lung tumor microenvironment to limit the development and progression of K-ras mutant lung cancer

Activating mutations of K-ras are the most common oncogenic alterations found in lung cancer. Unfortunately, attempts to target K-ras mutant lung tumors have thus far failed, clearly indicating the need for new approaches in patients with this molecular profile. We have previously shown NF-κB activa...

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Опубликовано в: :Cancer Res
Главные авторы: Caetano, Mauricio S., Zhang, Huiyuan, Cumpian, Amber M., Gong, Lei, Unver, Nese, Ostrin, Edwin J., Daliri, Soudabeh, Chang, Seon Hee, Ochoa, Cesar E., Hanash, Samir, Behrens, Carmen, Wistuba, Ignacio I., Sternberg, Cinthya, Kadara, Humam, Ferreira, Carlos Gil, Watowich, Stephanie S., Moghaddam, Seyed Javad
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891282/
https://ncbi.nlm.nih.gov/pubmed/27197187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2840
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