Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift

Single-cell RNA sequencing allows defining molecularly distinct cell subpopulations. However, the identification of specific sets of transcription factors (TFs) that define the identity of these subpopulations remains a challenge. Here we propose that subpopulation identity emerges from the synergis...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Okawa, Satoshi, Saltó, Carmen, Ravichandran, Srikanth, Yang, Shanzheng, Toledo, Enrique M., Arenas, Ernest, del Sol, Antonio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030214/
https://ncbi.nlm.nih.gov/pubmed/29968757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05016-8
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