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Mini-hemagglutinin vaccination induces cross-reactive antibodies in pre-exposed NHP that protect mice against lethal influenza challenge

Seasonal vaccines are currently the most effective countermeasure against influenza. However, seasonal vaccines are only effective against strains closely related to the influenza strains contained in the vaccine. Recently a new hemagglutinin (HA) stem-based antigen, the so-called “mini-HA”, has bee...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: van der Lubbe, Joan E. M., Huizingh, Jeroen, Verspuij, Johan W. A., Tettero, Lisanne, Schmit-Tillemans, Sonja P. R., Mooij, Petra, Mortier, Daniella, Koopman, Gerrit, Bogers, Willy M. J. M., Dekking, Liesbeth, Meijberg, Wim, Kwaks, Ted, Brandenburg, Boerries, Tolboom, Jeroen T. B. M., Schuitemaker, Hanneke, Roozendaal, Ramon, Kuipers, Harmjan, Zahn, Roland C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030213/
https://ncbi.nlm.nih.gov/pubmed/29977611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0063-7
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