Mini-hemagglutinin vaccination induces cross-reactive antibodies in pre-exposed NHP that protect mice against lethal influenza challenge

Seasonal vaccines are currently the most effective countermeasure against influenza. However, seasonal vaccines are only effective against strains closely related to the influenza strains contained in the vaccine. Recently a new hemagglutinin (HA) stem-based antigen, the so-called “mini-HA”, has bee...

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Publicat a:NPJ Vaccines
Autors principals: van der Lubbe, Joan E. M., Huizingh, Jeroen, Verspuij, Johan W. A., Tettero, Lisanne, Schmit-Tillemans, Sonja P. R., Mooij, Petra, Mortier, Daniella, Koopman, Gerrit, Bogers, Willy M. J. M., Dekking, Liesbeth, Meijberg, Wim, Kwaks, Ted, Brandenburg, Boerries, Tolboom, Jeroen T. B. M., Schuitemaker, Hanneke, Roozendaal, Ramon, Kuipers, Harmjan, Zahn, Roland C.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030213/
https://ncbi.nlm.nih.gov/pubmed/29977611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0063-7
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