Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo

Malignant mesothelioma is an aggressive cancer with poor prognosis. It is characterized by prominent extracellular matrix, mesenchymal tumor cell phenotypes and chemoresistance. In this study, the ability of pirfenidone to alter mesothelioma cell proliferation and migration as well as mesothelioma t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Li, Chang, Rezov, Veronika, Joensuu, Emmi, Vartiainen, Ville, Rönty, Mikko, Yin, Miao, Myllärniemi, Marjukka, Koli, Katri
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030186/
https://ncbi.nlm.nih.gov/pubmed/29968778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28297-x
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