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PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer

Chemotherapy represents an important treatment option for colorectal cancer (CRC), but only half of the patients benefit from these regimens. We explored the potential predicting value and mechanism of PIK3CA mutation in CRC chemotherapy. CRC specimens from 440 patients were retrospectively collecte...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Wang, Qiang, Shi, Yan-long, Zhou, Kai, Wang, Li-li, Yan, Ze-xuan, Liu, Yu-lin, Xu, Li-li, Zhao, Shi-wei, Chu, Hui-li, Shi, Ting-ting, Ma, Qing-hua, Bi, Jingwang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030128/
https://ncbi.nlm.nih.gov/pubmed/29970892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0776-6
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