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Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration

The tumor form of pyruvate kinase M2 has been suggested to promote cellular anabolism by redirecting the metabolism to cause accumulation of glycolytic intermediates and increasing flux through the pentose phosphate pathway, which is a metabolic pathway parallel to glycolysis. Both rod and cone phot...

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Podrobná bibliografie
Vydáno v:Cell Death Dis
Hlavní autoři: Rajala, Ammaji, Wang, Yuhong, Soni, Krutik, Rajala, Raju V. S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030055/
https://ncbi.nlm.nih.gov/pubmed/29970877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0712-9
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