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Pyruvate kinase M2 isoform deletion in cone photoreceptors results in age-related cone degeneration

The tumor form of pyruvate kinase M2 has been suggested to promote cellular anabolism by redirecting the metabolism to cause accumulation of glycolytic intermediates and increasing flux through the pentose phosphate pathway, which is a metabolic pathway parallel to glycolysis. Both rod and cone phot...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Rajala, Ammaji, Wang, Yuhong, Soni, Krutik, Rajala, Raju V. S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030055/
https://ncbi.nlm.nih.gov/pubmed/29970877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0712-9
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