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Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
Preservation of bone mass is crucial for healthy ageing and largely depends on adequate responses of matrix-embedded osteocytes. These cells control bone formation and resorption concurrently by secreting the WNT/β-catenin antagonist sclerostin (SOST). Osteocytes reside within a low oxygen microenvi...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6028485/ https://ncbi.nlm.nih.gov/pubmed/29967369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04679-7 |
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