Inhibiting the osteocyte-specific protein sclerostin increases bone mass and fracture resistance in multiple myeloma

Multiple myeloma (MM) is a plasma cell cancer that develops in the skeleton causing profound bone destruction and fractures. The bone disease is mediated by increased osteoclastic bone resorption and suppressed bone formation. Bisphosphonates used for treatment inhibit bone resorption and prevent bo...

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Pubblicato in:Blood
Autori principali: McDonald, Michelle M., Reagan, Michaela R., Youlten, Scott E., Mohanty, Sindhu T., Seckinger, Anja, Terry, Rachael L., Pettitt, Jessica A., Simic, Marija K., Cheng, Tegan L., Morse, Alyson, Le, Lawrence M. T., Abi-Hanna, David, Kramer, Ina, Falank, Carolyne, Fairfield, Heather, Ghobrial, Irene M., Baldock, Paul A., Little, David G., Kneissel, Michaela, Vanderkerken, Karin, Bassett, J. H. Duncan, Williams, Graham R., Oyajobi, Babatunde O., Hose, Dirk, Phan, Tri G., Croucher, Peter I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492093/
https://ncbi.nlm.nih.gov/pubmed/28515094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-773341
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