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Synthetic molecular evolution of hybrid cell penetrating peptides

Peptides and analogs such as peptide nucleic acids (PNA) are promising tools and therapeutics, but the cell membrane remains a barrier to intracellular targets. Conjugation to classical cell penetrating peptides (CPPs) such as pTat(48–60) (tat) and pAntp(43–68) (penetratin) facilitates delivery; how...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Kauffman, W. Berkeley, Guha, Shantanu, Wimley, William C.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028423/
https://ncbi.nlm.nih.gov/pubmed/29967329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04874-6
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