Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria

The GC skew in vertebrate mitochondrial genomes results in synthesis of RNAs that are prone to form G-quadruplexes (G4s). Such RNAs, although mostly non-coding, are transcribed at high rates and are degraded by an unknown mechanism. Here we describe a dedicated mechanism of degradation of G4-contain...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Pietras, Zbigniew, Wojcik, Magdalena A., Borowski, Lukasz S., Szewczyk, Maciej, Kulinski, Tomasz M., Cysewski, Dominik, Stepien, Piotr P., Dziembowski, Andrzej, Szczesny, Roman J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028389/
https://ncbi.nlm.nih.gov/pubmed/29967381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05007-9
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