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Long-read sequencing of nascent RNA reveals coupling among RNA processing events

Pre-mRNA splicing is accomplished by the spliceosome, a megadalton complex that assembles de novo on each intron. Because spliceosome assembly and catalysis occur cotranscriptionally, we hypothesized that introns are removed in the order of their transcription in genomes dominated by constitutive sp...

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Bibliografische gegevens
Gepubliceerd in:Genome Res
Hoofdauteurs: Herzel, Lydia, Straube, Korinna, Neugebauer, Karla M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028129/
https://ncbi.nlm.nih.gov/pubmed/29903723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.232025.117
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