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Long-read sequencing of nascent RNA reveals coupling among RNA processing events

Pre-mRNA splicing is accomplished by the spliceosome, a megadalton complex that assembles de novo on each intron. Because spliceosome assembly and catalysis occur cotranscriptionally, we hypothesized that introns are removed in the order of their transcription in genomes dominated by constitutive sp...

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Bibliografiska uppgifter
I publikationen:Genome Res
Huvudupphovsmän: Herzel, Lydia, Straube, Korinna, Neugebauer, Karla M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028129/
https://ncbi.nlm.nih.gov/pubmed/29903723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.232025.117
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