Genetic, dietary, and sex-specific regulation of hepatic ceramides and the relationship between hepatic ceramides and IR

Elevated hepatic ceramide levels have been implicated in both insulin resistance (IR) and hepatic steatosis. To understand the factors contributing to hepatic ceramide levels in mice of both sexes, we have quantitated ceramides in a reference population of mice, the Hybrid Mouse Diversity Panel that...

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Pubblicato in:J Lipid Res
Autori principali: Norheim, Frode, Bjellaas, Thomas, Hui, Simon T., Chella Krishnan, Karthickeyan, Lee, Jakleen, Gupta, Sonul, Pan, Calvin, Hasin-Brumshtein, Yehudit, Parks, Brian W., Li, Daniel Y., Bui, Hai H., Mosier, Marian, Wu, Yuping, Huertas-Vazquez, Adriana, Hazen, Stanley L., Gundersen, Thomas E., Mehrabian, Margarete, Tang, W. H. Wilson, Hevener, Andrea L., Drevon, Christian A., Lusis, Aldons J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027922/
https://ncbi.nlm.nih.gov/pubmed/29739864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M081398
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