Genetic, dietary, and sex-specific regulation of hepatic ceramides and the relationship between hepatic ceramides and IR

Elevated hepatic ceramide levels have been implicated in both insulin resistance (IR) and hepatic steatosis. To understand the factors contributing to hepatic ceramide levels in mice of both sexes, we have quantitated ceramides in a reference population of mice, the Hybrid Mouse Diversity Panel that...

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Vydáno v:J Lipid Res
Hlavní autoři: Norheim, Frode, Bjellaas, Thomas, Hui, Simon T., Chella Krishnan, Karthickeyan, Lee, Jakleen, Gupta, Sonul, Pan, Calvin, Hasin-Brumshtein, Yehudit, Parks, Brian W., Li, Daniel Y., Bui, Hai H., Mosier, Marian, Wu, Yuping, Huertas-Vazquez, Adriana, Hazen, Stanley L., Gundersen, Thomas E., Mehrabian, Margarete, Tang, W. H. Wilson, Hevener, Andrea L., Drevon, Christian A., Lusis, Aldons J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027922/
https://ncbi.nlm.nih.gov/pubmed/29739864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M081398
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