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Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations

Ball-milling is usually used to prepare co-amorphous drug–amino acid (AA) mixtures. In this study, co-amorphous drug–AA mixtures were produced using spray-drying, a scalable industrially preferred preparation method. The influence of the solvent type and solvent composition was investigated. Mixture...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Mishra, Jaya, Rades, Thomas, Löbmann, Korbinian, Grohganz, Holger
Format: Artigo
Language:Inglês
Published: MDPI 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027151/
https://ncbi.nlm.nih.gov/pubmed/29649124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics10020047
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