Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma

TWIST1 (TW) is a bHLH transcription factor (TF) and master regulator of the epithelial‐to‐mesenchymal transition (EMT). In vitro, TW promotes mesenchymal change, invasion, and self‐renewal in glioblastoma (GBM) cells. However, the potential therapeutic relevance of TW has not been established throug...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Mikheev, Andrei M., Mikheeva, Svetlana A., Severs, Liza J., Funk, Cory C., Huang, Lei, McFaline‐Figueroa, José L., Schwensen, Jeanette, Trapnell, Cole, Price, Nathan D., Wong, Stephen, Rostomily, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026950/
https://ncbi.nlm.nih.gov/pubmed/29754406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12320
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