Targeting TWIST1 through loss of function inhibits tumorigenicity of human glioblastoma

TWIST1 (TW) is a bHLH transcription factor (TF) and master regulator of the epithelial‐to‐mesenchymal transition (EMT). In vitro, TW promotes mesenchymal change, invasion, and self‐renewal in glioblastoma (GBM) cells. However, the potential therapeutic relevance of TW has not been established throug...

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Dades bibliogràfiques
Publicat a:Mol Oncol
Autors principals: Mikheev, Andrei M., Mikheeva, Svetlana A., Severs, Liza J., Funk, Cory C., Huang, Lei, McFaline‐Figueroa, José L., Schwensen, Jeanette, Trapnell, Cole, Price, Nathan D., Wong, Stephen, Rostomily, Robert C.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026950/
https://ncbi.nlm.nih.gov/pubmed/29754406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12320
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