Timeliness of Proteolytic Events Is Prerequisite for Efficient Functioning of the Alphaviral Replicase

Polyprotein processing has an important regulatory role in the life cycle of positive-strand RNA viruses. In the case of alphaviruses, sequential cleavage of the nonstructural polyprotein (ns-polyprotein) at three sites eventually yields four mature nonstructural proteins (nsPs) that continue workin...

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Publicat a:J Virol
Autors principals: Lulla, Valeria, Karo-Astover, Liis, Rausalu, Kai, Saul, Sirle, Merits, Andres, Lulla, Aleksei
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026757/
https://ncbi.nlm.nih.gov/pubmed/29695431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00151-18
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