Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

OBJECTIVE: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks. One prevailing theory is that impaired transport of leptin across the blood–brain barrier (BBB) represents a mol...

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Vydáno v:Mol Metab
Hlavní autoři: Kleinert, Maximilian, Kotzbeck, Petra, Altendorfer-Kroath, Thomas, Birngruber, Thomas, Tschöp, Matthias H., Clemmensen, Christoffer
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2018
Témata:
Brief Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026321/
https://ncbi.nlm.nih.gov/pubmed/29748097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.04.008
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