Hypothalamic leptin action is mediated by histone deacetylase 5

Hypothalamic leptin signalling has a key role in food intake and energy-balance control and is often impaired in obese individuals. Here we identify histone deacetylase 5 (HDAC5) as a regulator of leptin signalling and organismal energy balance. Global HDAC5 KO mice have increased food intake and gr...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kabra, Dhiraj G., Pfuhlmann, Katrin, García-Cáceres, Cristina, Schriever, Sonja C., Casquero García, Veronica, Kebede, Adam Fiseha, Fuente-Martin, Esther, Trivedi, Chitrang, Heppner, Kristy, Uhlenhaut, N. Henriette, Legutko, Beata, Kabra, Uma D., Gao, Yuanqing, Yi, Chun-Xia, Quarta, Carmelo, Clemmensen, Christoffer, Finan, Brian, Müller, Timo D., Meyer, Carola W., Paez-Pereda, Marcelo, Stemmer, Kerstin, Woods, Stephen C., Perez-Tilve, Diego, Schneider, Robert, Olson, Eric N., Tschöp, Matthias H., Pfluger, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773494/
https://ncbi.nlm.nih.gov/pubmed/26923837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10782
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