The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein–Barr virus by inhibiting the molecular chaperone function of Hsp70

Epstein–Barr virus (EBV) can infect cells in latent and lytic period and cause serious disease. Epstein–Barr virus nuclear antigen 1 (EBNA1) is essential for the maintenance of the EBV DNA episome, replication and transcription. 2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat...

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Pubblicato in:Cell Death Dis
Autori principali: Wang, Huan, Bu, Lang, Wang, Chao, Zhang, Yaqian, Zhou, Heng, Zhang, Xi, Guo, Wei, Long, Cong, Guo, Deyin, Sun, Xiaoping
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026193/
https://ncbi.nlm.nih.gov/pubmed/29959331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0779-3
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