Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper
Protein folding mediated by the Hsp70 family of molecular chaperones requires both ATP and the co-chaperone Hdj-1. BAG-1 was recently identified as a bcl-2-interacting, anti-apoptotic protein that binds to the ATPase domain of Hsp70 and prevents the release of the substrate. While this suggested tha...
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| Veröffentlicht in: | EMBO J |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2001
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145500/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11230127/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.5.1033 |
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