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Polymyxin B inhibits the chaperone activity of Plasmodium falciparum Hsp70

Heat shock protein 70 (Hsp70) is a molecular chaperone that plays an important role in cellular proteostasis. Hsp70s are also implicated in the survival and pathogenicity of malaria parasites. The main agent of malaria, Plasmodium falciparum, expresses six Hsp70s. Of these, two (PfHsp70-1 and PfHsp7...

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發表在:Cell Stress Chaperones
Main Authors: Zininga, Tawanda, Pooe, Ofentse J., Makhado, Pertunia B., Ramatsui, Lebogang, Prinsloo, Earl, Achilonu, Ikechukwu, Dirr, Heinrich, Shonhai, Addmore
格式: Artigo
語言:Inglês
出版: Springer Netherlands 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573689/
https://ncbi.nlm.nih.gov/pubmed/28455613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-017-0797-6
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