The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats

Chronic NP-1 administration reduces body weight and hepatic steatosis despite induction of tolerance in adiponectin gene transcription with respect to the acute actions of this drug. This study explored the hypothesis that NP-1 could exert these effects through mechanisms independent of adiponectin....

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Decara, Juan, Serrano, Antonia, Pavón, Francisco Javier, Rivera, Patricia, Arco, Rocio, Gavito, Ana, Vargas, Antonio, Navarro, Juan A., Tovar, Ruben, Lopez-Gambero, Antonio J., Martínez, Ana, Suárez, Juan, Rodríguez de Fonseca, Fernando, Baixeras, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026175/
https://ncbi.nlm.nih.gov/pubmed/29959379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27871-7
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