Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice

Interleukin-6 (IL-6) has emerged as an important mediator of fatty acid metabolism with paradoxical effects in the liver. Administration of IL-6 has been reported to confer protection against steatosis, but plasma and tissue IL-6 concentrations are elevated in chronic liver diseases, including fatty...

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Uloženo v:
Podrobná bibliografie
Vydáno v:Dis Model Mech
Hlavní autoři: Vida, Margarita, Gavito, Ana Luisa, Pavón, Francisco Javier, Bautista, Dolores, Serrano, Antonia, Suarez, Juan, Arrabal, Sergio, Decara, Juan, Romero-Cuevas, Miguel, Rodríguez de Fonseca, Fernando, Baixeras, Elena
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486858/
https://ncbi.nlm.nih.gov/pubmed/26035386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.019166
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