Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice

High-fat diet-induced obesity (DIO) is associated with fatty liver and elevated IL-6 circulating levels. IL-6 administration in rodents has yielded contradictory results regarding its effects on steatosis progression. In some models of fatty liver disease, high doses of human IL-6 ameliorate the liv...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Gavito, Ana Luisa, Bautista, Dolores, Suarez, Juan, Badran, Samir, Arco, Rocío, Pavón, Francisco Javier, Serrano, Antonia, Rivera, Patricia, Decara, Juan, Cuesta, Antonio Luis, Rodríguez-de-Fonseca, Fernando, Baixeras, Elena
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917096/
https://ncbi.nlm.nih.gov/pubmed/27333268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157956
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