CRISPR-Mediated Reactivation of DKK3 Expression Attenuates TGF-β Signaling in Prostate Cancer

The DKK3 gene encodes a secreted protein, Dkk-3, that inhibits prostate tumor growth and metastasis. DKK3 is downregulated by promoter methylation in many types of cancer, including prostate cancer. Gene silencing studies have shown that Dkk-3 maintains normal prostate epithelial cell homeostasis by...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Kardooni, Hoda, Gonzalez-Gualda, Estela, Stylianakis, Emmanouil, Saffaran, Sina, Waxman, Jonathan, Kypta, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025141/
https://ncbi.nlm.nih.gov/pubmed/29843383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10060165
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