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Rational Design of a Dephosphorylation-Resistant Reporter Enables Single-Cell Measurement of Tyrosine Kinase Activity

Although peptide-based reporters of protein tyrosine kinase (PTK) activity have been used to study PTK enzymology in vitro, the application of these reporters to intracellular conditions is compromised by their dephosphorylation, preventing PTK activity measurements. Non-proteinogenic amino acids ma...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Chem Biol
मुख्य लेखकों: Turner, Abigail H., Lebhar, Michael S., Proctor, Angela, Wang, Qunzhao, Lawrence, David S., Allbritton, Nancy L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6024252/
https://ncbi.nlm.nih.gov/pubmed/26587880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00667
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