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Evolutionary dynamics of paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by hemolysis and a high risk of thrombosis, that is due to a deficiency in several cell surface proteins that prevent complement activation. Its origin has been traced to a somatic mutation in the PIG-A gene...
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| Publicado no: | PLoS Comput Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6023248/ https://ncbi.nlm.nih.gov/pubmed/29912864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006133 |
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