Covalent capture of a human O(6)-alkylguanine alkyltransferase–DNA complex using N(1),O(6)-ethanoxanthosine, a mechanism-based crosslinker
The DNA repair protein O(6)-alkylguanine alkyltransferase (AGT) is responsible for removing promutagenic alkyl lesions from exocyclic oxygens located in the major groove of DNA, i.e. the O(6) and O(4) positions of guanine and thymine. The protein carries out this repair reaction by transferring the...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60232/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11574685/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.19.4025 |
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