Secretion, isotopic labeling and deglycosylation of N-acylethanolamine acid amidase for biophysical studies

N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) enzyme with a catalytic cysteine residue that has highest activity at acidic pH. The most prominent substrate hydrolyzed is palmitoylethanolamine (PEA), which regulates inflammation. Inhibitors of NAAA have been shown to incre...

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Udgivet i:Protein Expr Purif
Main Authors: Pavlopoulos, Spiro, Pelekoudas, Dimitrios N., Benchama, Othman, Rawlins, Catherine M., Agar, Jeffrey N., West, Jay M., Malamas, Michael, Zvonok, Nikolai, Makriyannis, Alexandros
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022831/
https://ncbi.nlm.nih.gov/pubmed/29253688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2017.12.005
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