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Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins
The intracellular pH (pHi) of most cancers is constitutively higher than that of normal cells and enhances proliferation and cell survival. We found that increased pHi enabled the tumorigenic behaviors caused by somatic arginine-to-histidine mutations, which are frequent in cancer and confer pH sens...
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| Publicado no: | Sci Signal |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6022362/ https://ncbi.nlm.nih.gov/pubmed/28874603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aam9931 |
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