Unexpected Replication Boost by Simeprevir for Simeprevir-Resistant Variants in Genotype 1a Hepatitis C Virus

Simeprevir is a novel NS3/4A protease inhibitor (PI) of hepatitis C virus (HCV). The baseline polymorphism NS3-Q80K is frequently observed in genotype (GT) 1a HCV and often associated with treatment failure in simeprevir-containing regimens. We aimed to elucidate mechanisms of treatment failure due...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Murai, Kazuhisa, Shimakami, Tetsuro, Welsch, Christoph, Shirasaki, Takayoshi, Liu, Fanwei, Kitabayashi, Juria, Tanaka, Shiho, Funaki, Masaya, Omura, Hitoshi, Nishikawa, Tomoki, Sumiyadorj, Ariunaa, Honda, Masao, Kaneko, Shuichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021633/
https://ncbi.nlm.nih.gov/pubmed/29661883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02601-17
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