Unexpected Replication Boost by Simeprevir for Simeprevir-Resistant Variants in Genotype 1a Hepatitis C Virus

Simeprevir is a novel NS3/4A protease inhibitor (PI) of hepatitis C virus (HCV). The baseline polymorphism NS3-Q80K is frequently observed in genotype (GT) 1a HCV and often associated with treatment failure in simeprevir-containing regimens. We aimed to elucidate mechanisms of treatment failure due...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Murai, Kazuhisa, Shimakami, Tetsuro, Welsch, Christoph, Shirasaki, Takayoshi, Liu, Fanwei, Kitabayashi, Juria, Tanaka, Shiho, Funaki, Masaya, Omura, Hitoshi, Nishikawa, Tomoki, Sumiyadorj, Ariunaa, Honda, Masao, Kaneko, Shuichi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021633/
https://ncbi.nlm.nih.gov/pubmed/29661883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02601-17
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars