Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

Whereas significant anti-tumor responses are observed in most BRAF(V600E)-mutant melanoma patients exposed to MAPK-targeting agents, resistance almost invariably develops. Here, we show that in therapy-responsive cells BRAF inhibition induces downregulation of the processing of Sterol Regulator Elem...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Talebi, Ali, Dehairs, Jonas, Rambow, Florian, Rogiers, Aljosja, Nittner, David, Derua, Rita, Vanderhoydonc, Frank, Duarte, Joao A. G., Bosisio, Francesca, Van den Eynde, Kathleen, Nys, Kris, Pérez, Mónica Vara, Agostinis, Patrizia, Waelkens, Etienne, Van den Oord, Joost, Fendt, Sarah-Maria, Marine, Jean-Christophe, Swinnen, Johannes V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021375/
https://ncbi.nlm.nih.gov/pubmed/29950559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04664-0
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados