Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy

Whereas significant anti-tumor responses are observed in most BRAF(V600E)-mutant melanoma patients exposed to MAPK-targeting agents, resistance almost invariably develops. Here, we show that in therapy-responsive cells BRAF inhibition induces downregulation of the processing of Sterol Regulator Elem...

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Pubblicato in:Nat Commun
Autori principali: Talebi, Ali, Dehairs, Jonas, Rambow, Florian, Rogiers, Aljosja, Nittner, David, Derua, Rita, Vanderhoydonc, Frank, Duarte, Joao A. G., Bosisio, Francesca, Van den Eynde, Kathleen, Nys, Kris, Pérez, Mónica Vara, Agostinis, Patrizia, Waelkens, Etienne, Van den Oord, Joost, Fendt, Sarah-Maria, Marine, Jean-Christophe, Swinnen, Johannes V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021375/
https://ncbi.nlm.nih.gov/pubmed/29950559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04664-0
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