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Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency
A series of nine compounds based on 3-[4-(benzyloxy)phenyl]propanoic acid core containing a 1-oxa-9-azaspiro[5.5]undecane periphery was designed, synthesized and evaluated as free fatty acid 1 (FFA1 or GPR40) agonists. The spirocyclic appendages included in these compounds were inspired by LY2881835...
Uloženo v:
| Vydáno v: | J Enzyme Inhib Med Chem |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Taylor & Francis
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6021034/ https://ncbi.nlm.nih.gov/pubmed/27781494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2016.1230110 |
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