Protein kinase C signaling dysfunction in von Willebrand disease (p.V1316M) type 2B platelets

von Willebrand disease (VWD) type 2B is characterized by gain-of-function mutations in von Willebrand factor (VWF), enhancing its binding affinity for the platelet receptor glycoprotein (GP)Ibα. VWD type 2B patients display a bleeding tendency associated with loss of high-molecular-weight VWF multim...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Casari, Caterina, Paul, David S., Susen, Sophie, Lavenu-Bombled, Cécile, Harroche, Annie, Piatt, Raymond, Poe, Kathryn O., Lee, Robert H., Bryckaert, Marijke, Christophe, Olivier D., Lenting, Peter J., Denis, Cécile V., Bergmeier, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020816/
https://ncbi.nlm.nih.gov/pubmed/29925524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017014290
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