Thrombin Provokes Degranulation of Platelet α-Granules Leading to the Release of Active Plasminogen Activator Inhibitor-1 (PAI-1)

BACKGROUND: The balance of fibrinolytic mediators is crucial to the survival of the critically ill patient, with tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) playing significant roles. While elevated levels of PAI-1 are associated with increased morbidity and mor...

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Pubblicato in:Shock
Autori principali: Huebner, Benjamin R, Moore, Ernest E, Moore, Hunter B, Stettler, Gregory R, Nunns, Geoffrey R, Lawson, Peter, Sauaia, Angela, Kelher, Marguerite, Banerjee, Anirban, Silliman, Christopher C
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019632/
https://ncbi.nlm.nih.gov/pubmed/29280928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001089
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