Evidence for Alternate Modes of B cell Activation Involving Fab Acquired-N-Glycosylations in Antibody Secreting Cells Infiltrating the Labial Salivary Glands of Sjögren’s Syndrome Patients

OBJECTIVE: To better understand the role of B cells, potential mechanisms for their aberrant activation, and the production of autoantibodies in the pathogenesis of Sjögren’s Syndrome (SS), we explored selection pressures and N-glycosylation acquired by somatic mutation (acN-glyc) in the immunoglobu...

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Опубликовано в: :Arthritis Rheumatol
Главные авторы: Koelsch, Kristi A., Cavett, Joshua, Smith, Kenneth, Moore, Jacen S., Lehoux, Sylvain D., Jia, Nan, Mather, Tim, Quadri, Syed M. S., Rasmussen, Astrid, Kaufman, C. Erick, Lewis, David M., Radfar, Lida, Scordino, Teresa A., Lessard, Christopher J., Kurien, Biji T., Cummings, Richard D., James, Judith A., Sivils, Kathy L., Farris, A. Darise, Scofield, R. Hal
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019603/
https://ncbi.nlm.nih.gov/pubmed/29457375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40458
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