Evidence for Alternate Modes of B cell Activation Involving Fab Acquired-N-Glycosylations in Antibody Secreting Cells Infiltrating the Labial Salivary Glands of Sjögren’s Syndrome Patients

OBJECTIVE: To better understand the role of B cells, potential mechanisms for their aberrant activation, and the production of autoantibodies in the pathogenesis of Sjögren’s Syndrome (SS), we explored selection pressures and N-glycosylation acquired by somatic mutation (acN-glyc) in the immunoglobu...

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Publicado no:Arthritis Rheumatol
Main Authors: Koelsch, Kristi A., Cavett, Joshua, Smith, Kenneth, Moore, Jacen S., Lehoux, Sylvain D., Jia, Nan, Mather, Tim, Quadri, Syed M. S., Rasmussen, Astrid, Kaufman, C. Erick, Lewis, David M., Radfar, Lida, Scordino, Teresa A., Lessard, Christopher J., Kurien, Biji T., Cummings, Richard D., James, Judith A., Sivils, Kathy L., Farris, A. Darise, Scofield, R. Hal
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019603/
https://ncbi.nlm.nih.gov/pubmed/29457375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40458
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