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Repair of triplex-directed DNA alkylation by nucleotide excision repair

Triplex-forming oligonucleotides (TFOs) are being investigated as highly specific DNA binding agents to inhibit the expression of clinically relevant genes. So far, they have been shown to inhibit transcription from the HER-2/neu gene in vitro, whereas their use in vivo has been studied to a limited...

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Autori principali: Ziemba, Amy, Derosier, L. Chris, Methvin, Russell, Song, Chun-Yan, Clary, Eric, Kahn, Wendy, Milesi, David, Gorn, Vladimir, Reed, Mike, Ebbinghaus, Scot
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC60196/
https://ncbi.nlm.nih.gov/pubmed/11691913
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